研究業績

原著論文・英文総説

  1. Hama S, Watanabe-Takahashi M, Nishimura H, Omi J, Tamada M, Saitoh T, Maenaka K, Okuda Y, Ikegami A, Kitagawa A, Furuta K, Izumi K, Shimizu E, Nishizono T, Fujiwara M, Miyasaka T, Takamori S, Takayanagi H, Nishikawa K, Kobayashi T, Toyama-Sorimachi N, Yamashita M, Senda T, Hirokawa T, Bito H, Nishikawa K.
    CaMKII-dependent non-canonical RIG-I pathway promotes influenza virus propagation in the acute-phase of infection.
    mBio 2025 Jan 8;16(1): e0008724. doi:10.1128/mbio.00087-24.
  2. Nagai M, Okawa T, Nakata K, Takahashi D, Miyajima R, Shiratori H, Yamanaka D, Nakamura A, Oyama C, Takahashi SI, Toyama-Sorimachi N, Suzuki K, Ohashi W, Dohi T, Kawamura YI, Hase K.
    Sugar and arginine facilitate oral tolerance by ensuring the functionality of tolerogenic immune cell subsets in the intestine.
    Cell Rep. 2024 43:114490. doi:10.1016/j.celrep.2024.114490
  3. Toyama-Sorimachi N.
    New approaches to the control of chronic inflammatory diseases with a focus on the endolysosomal system of immune cells.
    Int Immunol. 15:1401294. 10.1093/intimm/dxae041. 2024 <Invited Review>
  4. Karyu H, Niki T, Sorimachi Y, Hata S, Shimabukuro-Demoto S, Hirabayashi T, Mukai K, Kasahara K, Takubo K, Goda N, Honke K, Taguchi T, Sorimachi H, Toyama-Sorimachi N.
    Collaboration between a cis-interacting natural killer cell receptor and membrane sphingolipid is critical for the phagocyte function.
    Front Immunol. 2024 Apr 24;15: 1401294. doi:10.3389/fimmu.2024.1401294.eCollection 2024.
  5. Toyama-Sorimachi N.
    Sinking the carrier.
    Nat. Chem. Biol. <News & Views> doi:10.1038/s41589-023-01540-x. Online ahead of print. 2024.
  6. Kobayashi T. and Toyama-Sorimachi N*. 
    Metabolic control from the endolysosome: lysosome-resident amino acid transporters open novel therapeutic possibilities.
    Frontier in Immunology 14:1243104. doi:10.3389/fimmu.2023.1243104.
  7. Nguyen Tien D, Suzuki T, Kobayashi T, Toyama-Sorimachi N*, Dohmae N*.
    Identification of the interacting partners of a lysosomal membrane protein in living cells by BioID technique.
    STAR Protocols 2022 3(2):101263. doi:10.1016/j.xpro.2022.101263
  8. Karigane D, Haraguchi M, Toyama-Sorimachi N, Nishimura EK, Takubo K.
    Mitf is required for T cell maturation by regulating dendritic cell homing to the thymus.
    Biochem. Biophys. Res. Commun. 596:29-35. doi:10.1016/j.bbrc.2022.01.091.2022
  9. Kobayashi T, Nguyen Tien D, Toyama-Sorimachi N*.
    Lysosomal amino acid transporters as key players in inflammatory diseases.
    Int Immunol. 33(12):853-858 2021 doi:10.1093/intimm/dxab069. <Invited Review> 
  10. Kobayashi T‡, Nguyen Tien D‡, Sorimachi Y‡, Sugiura Y‡, Suzuki T, Karyu H, Shimabukuro-Demoto S, Ohshima D, Okamura T, Taguchi T, Ueki K, Kato N, Goda N, Dohmae N, Takubo K, Suematsu M, Noriko Toyama-Sorimachi*. (‡These authors contributed equally to this work)
    SLC15A4 mediates M1-prone metabolic shift in macrophages and guards immune cells from metabolic stress.
    Proc. Natl. Acad. Sci. U.S.A. 118(33):e2100295118. doi:10.1073/pnas.2100295118.2021
  11. Sasawatari S, Karyu H, Nguyen Tien D, Furuyama-Tanaka K, Toyama-Sorimachi N*.
    The inhibitory NK receptor Ly49Q protects plasmacytoid dendritic cells from pyroptotic cell death.
    Mol. Immunol. 135:217-225, 2021 doi:10.1016/j.molimm.2021.03.023. Epub 2021 Apr 28.
  12. Kobayashi T‡, Nguyen-Tien D‡, Ohshima D, Karyu H, Demoto-Shimabukuro S, Sugitani-Yoshida R, Toyama-Sorimachi N*. (‡These authors contributed equally to this work)
    Human SLC15A4 is crucial for TLR-mediated type I Interferon production and mitochondrial integrity.
    Int. Immunol. 33(7):399-406, 2021 doi:10.1093/intimm/dxab006.
  13. Shinkura R, Kang S, Arase H, Noriko Toyama-Sorimachi*.
    The 49th Annual Meeting of the Japanese Society for Immunology: COVID-19 and Immunity.
    Int Immunol. 33(4):193-196, 2021 doi:10.1093/intimm/dxab004.
  14. Chang HW, Kanegasaki S, Jin F, Deng Y, You Z, Chang J-H, Kim DY, Timilshina M, Jae-Ryong K, Lee YJ, Toyama-Sorimachi N, Tsuchiya T.
    A Common Signaling Pathway Leading to Degranulation in Mast Cells and Its Regulation by CCR1-ligand. Allergy 2020 75(6):1371-1381 doi:10.1111/all.14186.  Epub 2020 Feb 6.
  15. Kobayashi T, Shimabukuro-Demoto S, Tsutsui H, Toyama-Sorimachi N.*
    Type I interferon limits mast cell-mediated anaphylaxis by controlling secretory granule homeostasis. PLOS Biology 17 (11), e3000530 2019. doi:10.1371/journal.pbio.3000530
  16. Kikuchi J, Hori M, Iha H, Toyama-Sorimachi N, Hagiwara S, Kuroda Y, Koyama D, Izumi T, Yasui H, Suzuki A, Furukawa Y.
    Soluble SLAMF7 promotes the growth of myeloma cells via homophilic interaction with surface SLAMF7. Leukemia. 2019 Jul 29 34(1):180-195. doi:10.1038/s41375-019-0525-6.
  17. Watanabe-Takahashi M, Yamasaki S, Murata M, Kano F, Motoyama J, Yamate J, Omi J, Sato W, Ukai H, Shimasaki K, Ikegawa M, Tamura-Nakano M, Yanoshita R, Nishino Y, Miyazawa A, Natori Y, Toyama-Sorimachi N, Nishikawa K.
    Exosome-associated Shiga toxin 2 is released from cells and causes severe toxicity in mice.
    Sci Rep. 17;8(1):10776. doi:10.1038/s41598-018-29128-9. 2018
  18. Kobayashi T, Tsutsui H, Shimabukuro-Demoto S, Sugitani-Yoshida R, Karyu H, Furuyama-Tanaka K, Kato N, Okamura T, Ohshima D, Toyama-Sorimachi N.*
    Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells.
    Int. Immunol.     29(12):551-566. 2017 doi:10.1093/intimm/dxx063.
  19. Wang XX, Hu Y, Keep RF, Toyama-Sorimachi N, Smith DE.
    A novel role for PHT1 in the disposition of l-histidine in brain: In vitro slice and in vivo pharmacokinetic studies in wildtype and Pht1 null mice.
    Biochem Pharmacol. 15;124: 94-102, 2017 doi:10.1016/j.bcp.2016.11.012.
  20. Kobayashi T, Tanaka T, Toyama-Sorimachi N.*
    Separation of intracellular vesicles and Immunoassays.
    Bio-protocol 2015 doi:10.21769/BioProtoc.1571
  21. Seto E., Yoshida-Sugitani R., Kobayashi T., Toyama-Sorimachi N*.
    The assembly of EDC4 and Dcp1a into processing bodies is critical for the translational regulation of IL-6.
    PloS One 10(5):e0123223, 2015doi:10.1371/journal.pone.0123223.
  22. Nishimura D., Sakai H., Sato T., Sato F., Nishimura S., Toyama-Sorimachi N., Bartsch J.W., Sehara-Fujisawa A*.
    Roles of ADAM8 in elimination of injured muscle fibers prior to skeletal muscle regeneration.
    Mechanisms of Development 135:58-67, 2015 doi:10.1016/j.mod.2014.12.001. 
  23. Kobayashi T., Shimabukuro-Demoto S., Yoshida-Sugitani R., Furuyama-Tanaka K., Karyu H., Sugiura Y., Shimizu Y., Hosaka T., Goto M., Kato N., Okamura T., Suematsu M., Yokoyama S., and Toyama-Sorimachi N*. 
    The Histidine Transporter SLC15A4 Coordinates mTOR-Dependent Inflammatory Responses and Pathogenic Antibody Production.  
    Immunity 41(3):375-388, 2014 doi:10.1016/j.immuni.2014.08.011.
  24. Jin H., Arase N., Hirayasu K., Matsuoka S., Kohyama M., Suenaga T., Saito F., Tanimura K., Nakamaru Y., Matsuoka S., Ebina K., Shid K., Toyama-Sorimachi N., Yasuda S., Horita T., Hiwa R., Takasugi K.,  Ohmura K., Yoshikawa H., Saito T., Atsumi T., Sasazuki T., Katayama I., Lanier L.L., and Arase  H.  Autoantibodies to IgG/HLA-DR complexes are associated with rheumatoid arthritis susceptibility.  
    Proc. Natl. Acad. Sci. U.S.A. 111(10):3787-92, 2014 doi:10.1073/pnas.1401105111.
  25. Kobayashi T., Tanaka T. and Toyama-Sorimachi, N.*
    How cells optimize vesicular environments – control of the endosomal/lysosomal environment for efficient inflammatory responses.
    J. Biochem. 154(6):491-9, 2013 doi:10.1093/jb/mvt099. <Review article>
  26. Imanishi H., Takibuchi G., Kobayashi T., Ishikawa K., Nakada K., Mori M., Kikkawa Y., Takenega K., Toyama-Sorimachi N., and Hayashi J.-I. 
    Specific mtDNA Mutations in Mouse Carcinoma Cells Suppress Their Tumor Formation via Activation of The Host Innate Immune System.　
    Plos One8(9):e75981, 2013. doi:10.1371/journal.pone.0075981
  27. Onai N, Kurabayashi K, Hosoi-Amaike M, Toyama-Sorimachi N, Matsushima K, Inaba K, Ohteki T.
    A Clonogenic Progenitor with Prominent Plasmacytoid Dendritic Cell Developmental Potential.  Immunity 38(5):943-57. 2013.doi: 10.1016/j.immuni.2013.04.006
  28. Takibuchi G, Imanishi H, Morimoto M, Ishikawa K, Nakada K, Toyama-Sorimachi N, Kikkawa Y, Takenaga K, Hayashi JI.
    Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype. Mitochondrion 13(6):881-7, 2013 doi:10.1016/j.mito.2013.07.117
  29. Rahim MM, Tai LH, Troke AD, Mahmoud AB, Abou-Samra E, Roy JG, Mottashed A, Ault N, Corbeil C, Goulet ML, Zein HS, Hamilton-Valensky M, Krystal G, Kerr WG, Toyama-Sorimachi N, Makrigiannis AP.
    Ly49Q positively regulates type I IFN production by plasmacytoid dendritic cells in an immunoreceptor tyrosine-based inhibitory motif-dependent manner.
    J Immunol. 15;190(8):3994-4004, 2013. doi:10.4049/jimmunol.1200873
  30. Sasaki I, Hoshino K, Sugiyama T, Yamazaki C, Yano T, Iizuka A, Hemmi H, Tanaka T, Saito M, Sugiyama M, Fukuda Y, Ohta T, Sato K, Ainai A, Suzuki T, Hasegawa H, Toyama-Sorimachi N, Kohara H, Nagasawa T, Kaisho T.
    Spi-B is critical for plasmacytoid dendritic cell function and development. 
    Blood. 120(24):4733-43, 2012. doi:10.1182/blood-2012-06-436527
  31. Sasawatari, S., Okamura, T., Kasumi, E., Tanaka-Furuyama, K., Yanobu-Takanashi, R., Shirasawa, S., Kato, N. and Toyama-Sorimachi, N.*
    The solute carrier family15A4 regulates TLR9 and NOD1 functions in the innate immune system and promotes colitis in mice. 
    Gastroenterology 140:1513-25, 2011. doi:10.1053/j.gastro.2011.01.041
  32. Ishikawa, K., Toyama-Sorimachi, N.*(*corresponding author) , Nakada, K., Morimoto, M., Imanishi, H., Yoshizaki, M., Sasawatari, S., Niikura, M., Takenaga, K., Yonekawa, H., Hayashi, J.-I.* 
    The innate immune system in host mice targets cells with allogenic mitochondrial DNA. 
    J. Exp. Med. 207:2297-2305, 2010. doi:10.1084/jem.20092296
  33. Ojima K, Kawabata Y, Nakao H, Nakao K, Doi N, Kitamura F, Ono Y, Hata S, Suzuki H, Kawahara H, Bogomolovas J, Witt C, Ottenheijm C, Labeit S, Granzier H, Toyama-Sorimachi N, Sorimachi M, Suzuki K, Maeda T, Abe K, Aiba A, Sorimachi H.*　
    Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy.　
    J Clin Invest. 120(8):2672-83, 2010.  doi:10.1172/JCI40658
  34. Hata, S., Abe, M., Suzuki, H., Kitamura, F., Toyama-Sorimachi, N., Abe, K., Sakimura, K., and Sorimachi, H.*
    Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense. 
    PLoS Genetics 6:e1001040, 2010. doi:10.1371/journal.pgen.1001040
  35. Sasawatari, S, Yoshizaki, M, Taya C., Furuyama-Tanaka K., Yonekawa H., Dohi T., Makrigiannis A P, Sasazuki T., Inaba K., Toyama-Sorimachi N*.
    Ly49Q plays a crucial role in neutrophil polarization and migration by regulating raft trafficking.
    Immunity 32:200-213, 2010. doi:10.1016/j.immuni.2010.01.012
  36. Hayashi M, Nakashima T, Kodama T, Makrigiannis AP, Toyama-Sorimachi N, Takayanagi H*.　
    Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation.
    Biochem Biophys Res Commun. 393:432-438, 2010. doi:10.1016/j.bbrc.2010.02.013
  37. Yoshizaki M., Tazawa A., Kasumi E., Sasawatari S., Itoh K., Dohi T., Sasazuki T., Inaba K., Makrigiannis A.P. and Toyama-Sorimachi, N*.
    Spatiotemporal regulation of intracellular trafficking of TLR9 by an inhibitory receptor, Ly49Q.
    BLOOD 114:1518-27, 2009. doi:10.1182/blood-2008-12-192344
  38. Tai LH, Goulet ML, Belanger S, Toyama-Sorimachi N, Fodil-Cornu N, Vidal SM, Troke AD, McVicar DW, Makrigiannis AP*.
    Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC.
    J Exp Med. 205:3187-99, 2008. doi:10.1084/jem.20080718
  39. Mizutani N, Sakurai T, Shibata T, Uchida K, Fujita J, Kawashima R, Kawamura YI, Toyama-Sorimachi N, Imai T, Dohi T. *
    Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine. 
    J. Immunol. 179:7478-87, 2007. doi:10.4049/jimmunol.179.11.7478
  40. Hoshino A, Kawamura YI, Yasuhara M, Toyama-Sorimachi N, Yamamoto K, Matsukawa A, Lira SA, Dohi T.
    Inhibition of CCL1-CCR8 interaction prevents aggregation of macrophages and development of peritoneal adhesions. 
    J Immunol. 178:5296-304, 2007. doi:10.4049/jimmunol.178.8.5296
  41. Tai LH, Goulet ML, Belanger S, Troke AD, St-Laurent AG, Mesci A, Toyama-Sorimachi N*, Carlyle JR*, Makrigiannis AP*.
    Recognition of H-2K(b) by Ly49Q suggests a role for class Ia MHC regulation of plasmacytoid dendritic cell function.  
    Mol Immunol. 44:2638-46, 2007. (*these three authors equally contributed)
    doi:10.1016/j.molimm.2006.12.010
  42. Gays F, Aust JG, Reid DM, Falconer J, Toyama-Sorimachi N, Taylor PR, Brooks CG.
    Ly49B is expressed on multiple subpopulations of myeloid cells. 
    J Immunol. 177:5840-51, 2007. doi:10.4049/jimmunol.177.9.5840
  43. Kawashima R, Kawamura YI, Kato R, Mizutani N, Toyama-Sorimachi N, Dohi T.
    IL-13 receptor alpha2 promotes epithelial cell regeneration from radiation-induced small intestinal injury in mice.
    Gastroenterology131:130-41, 2006. doi:10.1053/j.gastro.2006.04.022
  44. Hata S, Koyama S, Kawahara H, Doi N, Maeda T, Toyama-Sorimachi N, Abe K, Suzuki K and Sorimachi H.
    Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta -subunit of coatomer complex, beta -COP.
    J Biol Chem. 281(16):11214-24, 2006 doi:10.1074/jbc.M509244200
  45. Omatsu, Y., Iyoda, T., Kimura, Y., Maki, A., Ishimori, M., Toyama-Sorimachi, N*. and Inaba, K*.
    Development of murine plasmacytoid dendritic cells defined by increased expression of an inhibitory NK receptor, Ly49Q. 
    J. Immunol. 174:6657-6662, 2005. doi:10.4049/jimmunol.174.11.6657
  46. Toyama-Sorimachi, N*., Omatsu, Y., Onoda, A., Tsujimura, Y., Iyoda, T., Kikuchi-Maki, A., Sorimachi, H., Dohi, T., Taki, S., Inaba, K., Karasuyama, H.
    Inhibitory NK receptor Ly49Q is expressed on subsets of  dendritic cells in a cellular maturation- and cytokine stimulation-dependent manner.
    J. Immunol. 174: 4621-4629, 2005. doi:10.4049/jimmunol.174.8.4621
  47. Shinohara H, Inoue A, Toyama-Sorimachi N, Nagai Y, Yasuda T, Suzuki H, Horai R, Iwakura Y, Yamamoto T, Karasuyama H, Miyake K, Yamanashi Y.
    Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling.
    J Exp Med. 201:333-339, 2005. doi:10.1084/jem.20041817
  48. Kawamura, Y. I., Kawashima, R., Fukunaga, R., Hirai, K., Toyama-Sorimachi, N., Tokuhara, M., Shimizu, T., and Dohi, T.
    Introduction of Sd(a) carbohydrate antigen in gastrointestinal cancer cells eliminates selectin ligands and inhibits metastasis. 
    Cancer Res.  65:6220-6227, 2005. doi:10.1158/0008-5472.CAN-05-0639
  49. Tsujimura, Y., Kikuchi-Maki, A., Dohi, T., Onoda, A., Koyasu, S., Inaba, K, Karasuyama, H. and Noriko Toyama-Sorimachi
    Ly49Q1 is expressed on myeloid lineage cells and involved in regulation of cell adhesiveness.  Immunology 2004, pp187-191.
  50. Toyama-Sorimachi,N.*, Tsujimura, Y., Maruya, M., Onoda, A., Kubota, T., Koyasu, S., Inaba, K. and Karasuyama, H.
    Ly49Q, a member of Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture. 
    Proc. Natl. Acad. Sci. USA. 101;1016-1021, 2004. doi:10.1073/pnas.0305400101
  51. Terauchi, M., Koi, H., Hayano, C., Toyama-Sorimachi, N., Karasuyama, H., Yamanashi, Y., Aso, T., and Shirakata, M.
    Placental extravillous cytotrophoblasts persistently express class I MHC molecules after human cytomegalovirus infection. 
    J. Viol. 77:8187-95, 2003. doi:10.1128/jvi.77.15.8187-8195.2003
  52. Wang, J.W., Howson, J.M., Ghansah, T., Desponts, C., Ninos, J.M., May, S.L., Nguyen, K.H., Toyama-Sorimachi, N., and Kerr. W.G.
    Influence of SHIP on the NK repertoire and allogeneic bone marrow transplantation.  
    Science. 15;295:2094-2097, 2002. doi:10.1126/science.1068438
  53. Tsuchiya K., Kawano Y., Kojima, T., Nagata, K., Takao, T., Okada, M., Shinohara, H., Maki, K., Toyama-Sorimachi, N., Miyasaka, M., Watanabe, M., and Karasuyama, H.
    Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase. 
    FEBS Let. 27023:1-7, 2003. doi:10.1016/s0014-5793(03)00127-3
  54. Minami J, Eishi Y, Ishige Y, Kobayashi I, Ishige I, Kobayashi D, Ando N, Uchida K, Ikeda S, Sorimachi N, Karasuyama H, Takemura T, Takizawa T, Koike M.
    Pulmonary granulomas caused experimentally in mice by a recombinant trigger-factor protein of Propionibacterium acnes.
    J Med Dent Sci. 50:265-74, 2003. doi:10.11480/jmds.500404
  55. Toyama-Sorimachi, N.*, Taguchi, Y., Yagita, H., Kitamura, F., Kawasaki, A., Koyasu, S. and Karasuyama, H.
    Mouse CD94 participates in Qa-1-mediated self recognition by NK cells and delivers inhibitory signals independent of Ly-49.  
    J. Immunol.  166:3771-3779, 2001. doi: 10.4049/jimmunol.166.6.3771
  56. Toyama-Sorimachi, N.*, Yagita, H., Kitamura, F., Kawasaki, A., Koyasu, S. and Karasuyama H.
    Functional characterization of mouse CD94 by using a novel monoclonal antibody.  
    Activating and Inhibitory Immunoglobulin-like Receptors. Cooper, M. D., Takai, T., Ravetch, J. V. eds.  Springer-Verlag Tokyo, 2001.
  57. Kinoshita, T., Nagata, K., Toyama-Sorimachi, N., Karasuyama, H., Sekiguchi, T. and Miyajima, A.
    Oncostatin M suppresses generation of lymphoid progenitors in fetal liver by inhibiting the hepatic microenvironment. 
    Exp. Hematl.  29:1091-1097, 2001. doi:10.1016/s0301-472x(01)00686-5
  58. Fujimoto, T., Kawashima, H., Tanaka, T., Hirose, M., Toyama-Sorimachi, N. and Miyasaka, M.
    CD44 binds a chondroitin sulfate proteoglycan, aggrecan. 
    Int. Immunol. 13:359-366, 2001. doi:10.1093/intimm/13.3.359
  59. Endo, J., Toyama-Sorimachi, N., Taya, C., Kuramochi-Miyagawa, S., Nagata, K., Kuida, K., Takashi, T., Yonekawa, H., Yoshizawa, Y., Miyasaka, N. and Karasuyama, H.
    Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes. 
    FEBS Letters,  468:234-238, 2000. doi:10.1016/s0014-5793(00)01219-9
  60. Tagawa, K., Taya, C., Hayashi, Y., Nakagawa, M., Ono, Y., Fukuda, R., Karasuyama, H., Toyama-Sorimachi, N., Katsui, Y., Hata, S., Ishiura, S., Nonaka, I., Seyama, Y., Arahata, K., Yonekawa, H., Sorimachi, H. and Suzuki, K.
    Myopathy phenotype of transgenic mice expressing active site-mutated inactive p94 skeletal muscle-specific calpain, the gene product responsible for limb girdle muscular dystrophy type 2A.      Human Mol. Genet.  9:1393-1402, 2000　
  61. Karasuyama, H., Tsuganezawa, K., Kiyokawa, N., Matsuo, Y., Kitamura, F., Toyama-Sorimachi, N., Kuida, K., and Fujimoto, J.
    Expression profile of pre-B cell receptor components in acute lymphoblastic leukemia and its application to the diagnosis and classification of the disease.  
    Tissue Antigens 55 (Supplement no. 1):20-21, 2000　
  62. Ishiwatari-Hayasaka, H., Osawa, T., Fujimoto, T., Hirama, T., Toyama-Sorimachi, N. and Miyasaka, M.
    Requirements for signal delivery through CD44. – Analysis using CD44-Fas chimeric proteins. 
    J. Immunol.  163:1258-1264, 1999.　
  63. Matsuoka, K., Taya, C., Kubo, S., Toyama-Sorimachi, N., Kitamura, F., Ra, C., Yonekawa, H., and Karasuyama, H.
    Establishment of antigen-specific IgE transgenic mice to study pathological and immunobiological roles of IgE in vivo.  
    Int. Immunol.  11:987-994, 1999.　
  64. Machida, H., Korenaga, R., Yamaguchi, M., Toyama-Sorimachi, N., Nakano, H., Kumada, K. and Ando, J.
    Effects of flow on neutrophil-mediated Ca2+ responses in human vascular endothelial cells. 
    Surgery Today,  29:966-969, 1999.　
  65. Tsuganezawa, K., Kiyokawa, N., Matsuo, Y., Kitamura, F., Toyama-Sorimachi, N., Kuida, K., Fujimoto, J. and Karasuyama, H.
    Flow cytometoric diagnosis of the cell lineage and developmental stage of acute lymphoblastic leukemia by novel monoclonal antibodies specific to human pre-B-cell receptor.  
    Blood, 92:1-9, 1998.
  66. Tsuzuki, S., Toyama-Sorimachi, N., Kitamura, F. and Miyasaka, M.
    FK506 (tacrolimus) inhibits extravasation of lymphoid cells by abrogating VLA-4/VCAM-1 mediated transendothelial migration. 　
    FEBS Letters,  430:414-418, 1998.　
  67. Tsuzuki, S., Toyama-Sorimachi, N., Kitamura, F., Tsuboi, H., Ando, J., Sakurai, T., Morii, N., Narumiya, S. and Miyasaka, M.
    Analysis of intracellular signal-transducing elements involved in transendothelial migration of lymphoma cells.  
    J. J. Cancer Res., 89:571-577, 1998.
  68. Toyama-Sorimachi, N., Kitamura, F., Habuchi, H., Tobita, Y., Kimata, K. and Miyasaka, M.
    Widespread expression of chondroitin sulfate type serglycins with CD44 binding ability in hemopoietic cells. 
    J. Biol. Chem.  272:26714-26719, 1997.
  69. Emoto, K., Toyama-Sorimachi, N., Karasuyama, H., Inoue, K. and Umeda, M.
    Exposure of phosphatidylethanolamine on the surface of apoptotic cells.  Exp. Cell Res.  232:430-434, 1997
  70. Shimabukuro, K., Toyama-Sorimachi, N., Ozaki, Y., Goi, T., Furukawa, K., Miyasaka, M. and Aso, T.
    The expression patterns of standard and variant CD44 molecules in normal uterine cervix and cervical cancer. 
    Gynecologic Oncology  64:26-34, 1997　
  71. Toyama-Sorimachi, N.*
    CD44 and its ligands. 
    Biotherapy   10:565-573, 1996　
  72. Sorimachi, H., Kinbara, K., Kimura, S., Takahashi, M., Ishiura, S., Sasagawa, N., Toyama-Sorimachi, N., Shimada, H., Tagawa, K., Maruyama, K. and Suzuki, K.
    Muscle-specific calpain, p94, responsible for limb girdle muscular dystrophy type 2A, associates with connectin through IS2, a p94-specific sequence. 
    J. Biol. Chem.  270:31158-31162, 1995.　
  73. Toyama-Sorimachi, N., Sorimachi, H., Tobita, Y., Kitamura, F., Yagita, H., Suzuki, K. and Miyasaka, M.
    A novel ligand for CD44 is serglycinn, a hematopoietic cell lineage specific proteoglycan – possible involvement in lymphoid cell adherence and activation.  
    J. Biol. Chem.  270:7437-7444, 1995.　
  74. Ando, J., Tsuboi, H., Korenaga, R., Takada, Y., Toyama-Sorimachi, N., Miyasaka, M. and Kamiya, A.
    Down-regulation of vascular adhesion molecule-1 by fluid shear stress in cultured mouse endothelial cells.  
    Annal. New York Acad. Sci.  748:148-157, 1995.　
  75. Toyama-Sorimachi, N. and Miyasaka, M.
    A sulfated proteoglycan as a novel lingad for CD44.  J. Dermatol.   21:795-801, 1994.　
  76. Yoshida, T., Toyama-Sorimachi, N., Miyasaka, M. and Lee, Y. C.
    A crucial effect of ligand clustering on the inhibition of binding by L-selectin in intercellular adhesion.
    Biochem. Biophys. Res. Com.   204:969-974, 1995.　
  77. Toyama-Sorimachi, N. and Miyasaka, M.
    A novel ligand for CD44 is sulfated proteoglycan.
    Int. Immunol.6:655-660, 1994.　
  78. Ando, J., Tsuboi, H., Korenaga, R., Takada, Y., Toyama-Sorimachi, N., Miyasaka, M. and Kamiya, A.
    Shear stress inhibits adhesion of cultured mouse endothelial cells to lymphocytes by downregulating VCAM-1 expression. 
    Am. J. Physiol.267:C679-C87, 1994.　
  79. Toyama-Sorimachi, N., Lianguo, W., Ando, J., Sakurai, T. and Miyasaka, M.
    Analysis of intracellular signaling in transendothelial migration of tumor cells. 
    J. Cell. Biochem.Abstract Supplement 18C, p247, 1994.　
  80. Sorimachi, H., Toyama-Sorimachi, N., Ishiura, S. and Suzuki, K.
    Identification and localization of a novel muscle-specific calpain, p94.  
    Proteolysis and protein turn over(eds. Bond, J.S. and Barrett, A.J.) pp45-49, 1994.　
  81. Ohtsuka, A., Ando, J., Korenaga, R., Kamiya, A., Sorimachi-Toyama, N. and Miyasaka, M.;
    The effect of flow on the expression of vascular adhesion molecule-1 by cultured mouse endothelial cells. 
    Biochem. Biophys. Res. Commun.  193:303-310, 1993.　
  82. Toyama-Sorimachi, N., Miyake, K. and Miyasaka, M.
    Activation of CD44 induces ICAM-1/LFA-1 independent, Ca2+, Mg2+-independent adhesion pathway in lymphocyte-endothelial cell interaction.
    Eur. J. Immunol.  23:439-446, 1993.　
  83. Toyama-Sorimachi, N. and Miyasaka, M.
    Adhesion molecule-Signaling molecules at the lymphocyte-endothelial interface.  
    Molecular Basis of Immune Responses.  Academic Press.  pp49-57, 1993.
  84. Sorimachi, H., Toyama-Sorimachi, N., Saido, T. C., Kawasaki, H., Sugita, H., Miyasaka, M., Arahata, K. Ishiura, S. and Suzuki, K.
    Muscle-specific calpain, p94, is degraded by autolysis immediately after translation, resulting in disappearance from muscle.  
    J. Biol. Chem.  268:10593-10605, 1993.　
  85. Kuida, K., Tanaka, T., Kitamura, F., Toyama-Sorimachi, N. and Miyasaka, M.
    Reconstitution of the intermediate-affinity interleukin-2 receptor by cell fusion. 
    Int. Immunol.  4:1123-1128, 1992.　
  86. Tanaka, T., Tsudo, M., Karasuyama, H., Toyama, N., Hatakeyama, M., Taniguchi, T. and Miyasaka, M.
    Signal transduction through the human IL-2 receptor b-chain expressed in IL-6-dependent mouse B cell hybridoma. 
    Int. Immunol. 3:105-108, 1991.　
  87. Tohyama, N., Karasuyama, H. and Tada, T.
    Growth autonomy and tumorigenicity of interleukin 6-dependent B cells transfected with interleukin 6 cDNA. 
    J. Exp. Med.  171:389-400, 1990.　
  88. Karasuyama, H., Tohyama, N. and Tada, T.
    Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene.  
    J. Exp. Med.  169:13-25, 1989.

日本語総説（直近10年のみ掲載）

  • 反町典子、善光龍哉、井上豪：BINDSプラットフォームで実現する近未来の創薬エコシステム　細胞　10月号　2025
  • 反町典子：12回膜貫通の難敵トランスポーターを標的として難病治療薬に挑む　実験医学増刊号（アカデミア創薬の実践、善光達哉、辻川和丈編）42:227-235, 2024.
  • 反町典子：Senolysisと細胞競合―不都合な細胞を排除する生体恒常性のしくみ―　炎症と免疫 31:1-2, 2023.
  • 小林俊彦、反町典子：エンドソーム・リソソームが担う炎症応答と新たな治療戦略　Clinical Neuroscience Vol. 40, No. 7　2022
  • 小林俊彦、反町典子：エンドリソソームを標的とする新たな炎症制御戦略　生体の科学 73(3): 　(金原一郎記念医学医療振興財団)　2022
  • 小林俊彦、反町典子：「エンドリソソーム局在型アミノ酸トランスポーターSLC15A4によるマクロファージの代謝調節を介した炎症応答の制御機構」　臨床免疫・アレルギー科 77:637-644, 2022
  • 反町典子：創薬研究者が知っておくべき新しい免疫学　分担執筆（3章1節）「自己免疫疾患の発症/制御に関わる重要な鍵分子を求めて　―内因性炎症を担う鍵分子の探索戦略と最新の知見―」 技術情報協会　2021
  • 小林俊彦、反町典子：アミノ酸トランスポーターがになうマクロファージの栄養代謝シグナルと炎症制御. 炎症と免疫　先端医学社 29;17-23, 2021
  • 小林俊彦、反町典子：1型インターフェロンによるマスト細胞機能の制御機構　臨床免疫・アレルギー科　74:271-276, 2020 科学評論社
  • 反町典子、小林俊彦：リソソーム局在型アミノ酸トランスポーターを標的とした免疫難病治療への挑戦　医学のあゆみ第一土曜特集 271:17-25, 2019 医歯薬出版株式会社
  • 反町典子、Nguyen Tien Dat、小林俊彦：オルガネラを基軸とした炎症制御機構の理解と疾患治療戦略　臨床免疫・アレルギー科 72:313-321, 2019 科学評論社
  • 小林俊彦、向井康治朗、田口友彦、反町典子：炎症･感染応答を担うオルガネラ　臨床免疫･アレルギー科 69:99-106, 2018　科学評論社　
  • 反町典子、小林俊彦：エンドリソソーム環境に依存した自然免疫応答偏向　医学のあゆみ　265:1094-1100, 2018 医歯薬出版株式会社
  • 田口友彦，小林俊彦，反町典子，仁木隆裕：リポクオリティ認識プローブの開発と応用　実験医学36:217-221, 2018　羊土社
  • 小林俊彦、向井康治朗、田口友彦、反町典子：炎症･感染応答を担うオルガネラ. 感染免疫アレルギー科 69(1)2018　
  • 反町典子：細胞膜の機能的区画化におけるクラスターとドメインの概念とその制御. 生体の科学 特集号「脂質ワールド」67(3):220-226, 2016
  • 小林俊彦、反町典子：細胞内アミノ酸輸送に依存した新たなTLRシグナル制御機構. 細胞工学134:557-561, 2015
  • 反町典子、小林俊彦：リソソーム環境に依存した炎症シグナルと自己免疫疾患の病態. 実験医学増刊号「自己免疫疾患－新たな発症メカニズムと治療戦略」33:75-82, 2015
  • 小林俊彦、反町典子：リソソームに局在するアミノ酸輸送体SLC15A4による炎症応答の制御　 ライフサイエンス新着論文レビュー http://first.lifesciencedb.jp/archives/9333  2014.

著書

  • 反町典子：医学大辞典　第3版　医学書院　分担執筆
  • 反町典子：医学大辞典　南山堂　分担執筆
  • 反町典子：分子生物学・免疫学キーワード辞典　医学書院　分担執筆
  • 反町洋之、反町典子：免疫の反逆（翻訳）三田出版
  • 反町典子：エッセンシャル化学辞典　東京化学同人　分担執筆　

他多数

受賞

  • 2022年　NCGM Director’s award 最優秀賞
  • 2018年　第5回日本免疫学会女性研究者賞
  • 2013年　第2回箱根山賞受賞（NCGM最優秀賞）
  • 2010年　Nature Immunology ポスター賞
  • 1995年　免疫研究フォーラム賞受賞

特許

  • PCT/JP2022/028695. THERAPEUTIC AGENT FOR PULMONARY FIBROSIS. Noriko Toyama-Sorimachi, Toshihiko Kobayashi, Dat Nguyen-Tien. National Center for Global Health and Medicine, 2022.7.26.
  • PCT/JP2022/028849. TREATMENT AND REHABILITATION METHOD FOR PULMONARY FIBROSIS. Noriko Toyama-Sorimachi, Toshihiko Kobayashi, Dat Nguyen-Tien, Haruto Sugiyama, Shinyu Izumi, Takao Oomagari. National Center for Global Health and Medicine, 2022.7.26.
  • 特願2021-121767.肺線維症治療剤.　反町典子, 小林俊彦, グェン ティエン ダット.　国立国際医療研究センター.　2021.7.26.
  • 特願2021-122043.肺線維症の治療および修復方法.　反町典子, 小林俊彦, グェン ティエン ダット, 杉山温人, 泉信有, 大曲貴夫. 国立国際医療研究センター. 2021.7.26.
  • 特記事項として、1，2および自己免疫疾患の新規医薬品リード化合物を2024年にグローバルメガファーマへ導出

その他

  • 公益財団法人 加藤記念バイオサイエンス振興財団評議員
  • 大阪大学蛋白質研究所専門委員会委員
  • 日本学術振興会　科学研究費委員会専門委員　
  • 革新的先端研究開発支援事業（AMED-CREST, PRIME）領域評価委員
  • 文部科学省　学術変革領域研究専門委員会委員
  • 日本学術会議二部連携会員
  • International Immunology Associate Editor
  • Frontiers in Immunology Review editor

東京大学大学院 理学系研究科 生物科学専攻

分子炎症免疫学研究室 反町研究室

〒113-0032 東京都文京区弥生2-11-16

Sorimachi Laboratory

Molecular Immunology and Inflammation
Department of Biological Sciences, Graduate School of Science
The University of Tokyo

2-11-16 Yayoi, Bunkyo-ku,Tokyo 113-0032, Japan

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